AcNo Complex 15mL AcNo Complex takes a holistic approach to treating inflammation, irritation and combatting acne bacteria. It brings immediate relief but also takes a long-term approach – for skin as well as lifestyle. It reduces the heat and discomfort caused by inflammation and reduces the frequency and sensitivity of flare-ups. Binding Aesthetics & Science. AcNo Complex is a concentrated and effective mixture of antibacterial substances used to treat irritated and problematic skin. It reduces sebum production and inhibits oiliness of the skin. AcNo Complex decreases redness and blemishes, while hydrating, soothing and improving the skin’s moisture level.